Chemical Name: N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
RORag inverse agonist
Molecular Weight:
477.39
Purity:
98% by TLC, NMR (conforms)
Form:
Cream-colored solid
CAS Number:
[1335106-03-0]
Formula:
C15H13F6N6O4S2
Application Notes:
A high affinity synthetic ligand for both RORalpha and RORgammat acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo
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