A83-01, CAS [[909910-43-6]]

Produktübersicht

• Artikelname: A83-01, CAS [[909910-43-6]]
• Artikelnummer: FBM-10-1327
• Hersteller Artikelnummer: 10-1327
• Alternativnummer: FBM-10-1327-5MG, FBM-10-1327-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Produktbeschreibung

ALK inhibitor

Produkteigenschaften

• Molekulargewicht: 421.53
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Light yellow solid
• CAS Nummer: [909910-43-6]
• Formel: C25H19N5S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFbeta2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.