A83-01, CAS [[909910-43-6]]

Product Overview

• Article Name: A83-01, CAS [[909910-43-6]]
• Biozol Catalog Number: FBM-10-1327
• Supplier Catalog Number: 10-1327
• Alternative Catalog Number: FBM-10-1327-5MG,FBM-10-1327-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

ALK inhibitor

Product Properties

• Molecular Weight: 421.53
• Purity: 98% by TLC, NMR (Conforms)
• Form: Light yellow solid
• CAS Number: [909910-43-6]
• Formula: C25H19N5S

Application Notes

• Application Notes: Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFbeta2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.