Chemical Name: 2S,3S-trans-(Ethoxycarbonyloxirane-2-carbonyl)-L-leucine-(3-methylbutyl)amide. Alternate Names: Aloxistatin, Loxistatin
Cysteine protease inhibitor
Molekulargewicht:
342.43
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
White or off-white solid
CAS Nummer:
[88321-09-9]
Formel:
C17H30N2O5
Anwendungsbeschreibung:
Cell-permeable derivative of E-64c, an inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B and cathepsin L.1,2 Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the ethyl ester and reduce cell permeability. Typical working concentration is 0.5-10 µg/ml. Inhibits degradation of autophagic cargo inside autolysosomes3
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