Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid. Alternate Names: N-(Dimethylamino)succinamic acid
KDM2/7 demethylase inhibitor
Molekulargewicht:
160.17
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[1596-84-5]
Formel:
C6H12N2O3
Anwendungsbeschreibung:
A selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 µM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50>100 µM1.
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