NSC697923, CAS [[343351-67-7]]

Produktübersicht

• Artikelname: NSC697923, CAS [[343351-67-7]]
• Artikelnummer: FBM-10-1418
• Hersteller Artikelnummer: 10-1418
• Alternativnummer: FBM-10-1418-5MG, FBM-10-1418-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[(Methylphenyl)sulfonyl]-5-nitrofuran

Produktbeschreibung

Ubiquitin E2 Conjugating enzyme inhibitor

Produkteigenschaften

• Molekulargewicht: 267.26
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: pink solid
• CAS Nummer: [343351-67-7]
• Formel: C11H9NO5S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-kappaB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells1. Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. Acts via covalent bonding to E2 active site thiol2,3. Induces neuroblastoma cell death via activation of p53 and JNK4.