NSC697923, CAS [[343351-67-7]]

Product Overview

• Article Name: NSC697923, CAS [[343351-67-7]]
• Biozol Catalog Number: FBM-10-1418
• Supplier Catalog Number: 10-1418
• Alternative Catalog Number: FBM-10-1418-5MG, FBM-10-1418-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[(Methylphenyl)sulfonyl]-5-nitrofuran

Product Description

Ubiquitin E2 Conjugating enzyme inhibitor

Product Properties

• Molecular Weight: 267.26
• Purity: 98% by TLC, NMR (Conforms)
• Form: pink solid
• CAS Number: [343351-67-7]
• Formula: C11H9NO5S

Application Notes

• Application Notes: Selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-kappaB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells1. Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. Acts via covalent bonding to E2 active site thiol2,3. Induces neuroblastoma cell death via activation of p53 and JNK4.