CCG-4986, CAS [[7134-19-2]]

Produktübersicht

• Artikelname: CCG-4986, CAS [[7134-19-2]]
• Artikelnummer: FBM-10-1431
• Hersteller Artikelnummer: 10-1431
• Alternativnummer: FBM-10-1431-5MG,FBM-10-1431-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

RGS4 inhibitor

Produkteigenschaften

• Molekulargewicht: 374.81
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [7134-19-2]
• Formel: C13H11ClN2O5S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: CCG-4986 is the first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4.1 It covalently2-3 modifies RGS4 by inhibiting its interaction with Galpha (IC50 = 3-5 mM) and suppressing GTPase activity1. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling.4 A novel tool for exploring the involvement of RGS4 in physiological processes.5