CCG-4986, CAS [[7134-19-2]]

Product Overview

• Article Name: CCG-4986, CAS [[7134-19-2]]
• Biozol Catalog Number: FBM-10-1431
• Supplier Catalog Number: 10-1431
• Alternative Catalog Number: FBM-10-1431-5MG, FBM-10-1431-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate

Product Description

RGS4 inhibitor

Product Properties

• Molecular Weight: 374.81
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [7134-19-2]
• Formula: C13H11ClN2O5S2

Application Notes

• Application Notes: CCG-4986 is the first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4.1 It covalently2-3 modifies RGS4 by inhibiting its interaction with Galpha (IC50 = 3-5 mM) and suppressing GTPase activity1. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling.4 A novel tool for exploring the involvement of RGS4 in physiological processes.5