ML-SA1, CAS [[332382-54-4]]

Produktübersicht

• Artikelname: ML-SA1, CAS [[332382-54-4]]
• Artikelnummer: FBM-10-1439
• Hersteller Artikelnummer: 10-1439
• Alternativnummer: FBM-10-1439-10MG, FBM-10-1439-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Produktbeschreibung

TRPML activator

Produkteigenschaften

• Molekulargewicht: 362.43
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Tan solid
• CAS Nummer: [332382-54-4]
• Formel: C22H22N2O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 µM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 µM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4