ML-SA1, CAS [[332382-54-4]]

Product Overview

• Article Name: ML-SA1, CAS [[332382-54-4]]
• Biozol Catalog Number: FBM-10-1439
• Supplier Catalog Number: 10-1439
• Alternative Catalog Number: FBM-10-1439-10MG, FBM-10-1439-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Product Description

TRPML activator

Product Properties

• Molecular Weight: 362.43
• Purity: 98% by HPLC NMR (Conforms)
• Form: Tan solid
• CAS Number: [332382-54-4]
• Formula: C22H22N2O3

Application Notes

• Application Notes: TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 µM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 µM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4