GSK-1702934A, CAS [[924377-85-5]]

Produktübersicht

• Artikelname: GSK-1702934A, CAS [[924377-85-5]]
• Artikelnummer: FBM-10-1445
• Hersteller Artikelnummer: 10-1445
• Alternativnummer: FBM-10-1445-5MG,FBM-10-1445-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

TRPC3/6 activator

Produkteigenschaften

• Molekulargewicht: 396.53
• Reinheit: 98% by TLC (5% CH3OH in CH2Cl2 Rf=0.34)
• Formulierung: White solid
• CAS Nummer: [924377-85-5]
• Formel: C22H26N3O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 µM and 0.44 µM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1µM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1µM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2