GSK-1702934A, CAS [[924377-85-5]]

Product Overview

• Article Name: GSK-1702934A, CAS [[924377-85-5]]
• Biozol Catalog Number: FBM-10-1445
• Supplier Catalog Number: 10-1445
• Alternative Catalog Number: FBM-10-1445-5MG, FBM-10-1445-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(1-(5,6,7,8-Tetrahydro=4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one

Product Description

TRPC3/6 activator

Product Properties

• Molecular Weight: 396.53
• Purity: 98% by TLC (5% CH3OH in CH2Cl2 Rf=0.34)
• Form: White solid
• CAS Number: [924377-85-5]
• Formula: C22H26N3O2S

Application Notes

• Application Notes: TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 µM and 0.44 µM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1µM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1µM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2