AI-1, CAS [[75483-04-4]]

Produktübersicht

• Artikelname: AI-1, CAS [[75483-04-4]]
• Artikelnummer: FBM-10-1471
• Hersteller Artikelnummer: 10-1471
• Alternativnummer: FBM-10-1471-5MG,FBM-10-1471-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Produktbeschreibung

Nrf2 activator

Produkteigenschaften

• Molekulargewicht: 265.70
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [75483-04-4]
• Formel: C13H12ClNO3

Anwendungsbeschreibung

• Anwendungsbeschreibung: A novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable.

Bilder

10-1471