AI-1, CAS [[75483-04-4]]

Product Overview

• Article Name: AI-1, CAS [[75483-04-4]]
• Biozol Catalog Number: FBM-10-1471
• Supplier Catalog Number: 10-1471
• Alternative Catalog Number: FBM-10-1471-5MG, FBM-10-1471-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Product Description

Nrf2 activator

Product Properties

• Molecular Weight: 265.70
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [75483-04-4]
• Formula: C13H12ClNO3

Application Notes

• Application Notes: A novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable.