PRT4165, CAS [[31083-55-3]]

Produktübersicht

• Artikelname: PRT4165, CAS [[31083-55-3]]
• Artikelnummer: FBM-10-1478
• Hersteller Artikelnummer: 10-1478
• Alternativnummer: FBM-10-1478-10MG, FBM-10-1478-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione

Produktbeschreibung

E3 ubiquitin ligase inhibitor

Produkteigenschaften

• Molekulargewicht: 235.24
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [31083-55-3]
• Formel: C15H9NO2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 µM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2