PRT4165, CAS [[31083-55-3]]

Product Overview

• Article Name: PRT4165, CAS [[31083-55-3]]
• Biozol Catalog Number: FBM-10-1478
• Supplier Catalog Number: 10-1478
• Alternative Catalog Number: FBM-10-1478-10MG,FBM-10-1478-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

E3 ubiquitin ligase inhibitor

Product Properties

• Molecular Weight: 235.24
• Purity: 98% by TLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [31083-55-3]
• Formula: C15H9NO2

Application Notes

• Application Notes: Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 µM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2