Chemical Name: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)dopamine. Alternate Names: NADA, AA-DA, N-Arachidonoyldopamine
Endogenous TRPV1 activator
Molekulargewicht:
439.63
Reinheit:
98% by TLC NMR (Conforms)
Formulierung:
Pale yellow viscous oil
CAS Nummer:
[199875-69-9]
Formel:
C28H41NO3
Anwendungsbeschreibung:
Endogenous conjugate of arachidonic acid and dopamine.1 May be the ''endogenous capsaicin like substance in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 M for CB1 and CB2 respectively)2 and results in a distinct signaling profile from any known cannabinoid3. Competitive inhibitor of FAAH and anadamide transport.4. Modulates acute systemic inflammation via non-hematopoietic TRPV1.5
10-1479
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