Endogenous conjugate of arachidonic acid and dopamine.1 May be the ''endogenous capsaicin like substance in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 M for CB1 and CB2 respectively)2 and results in a distinct signaling profile from any known cannabinoid3. Competitive inhibitor of FAAH and anadamide transport.4. Modulates acute systemic inflammation via non-hematopoietic TRPV1.5
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