ISRIB, CAS [[1597403-47-8]]

Produktübersicht

• Artikelname: ISRIB, CAS [[1597403-47-8]]
• Artikelnummer: FBM-10-1539
• Hersteller Artikelnummer: 10-1539
• Alternativnummer: FBM-10-1539-5MG, FBM-10-1539-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N.N-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide. Alternate Names: trans-ISRIB

Produktbeschreibung

Integrated stress response inhibitor

Produkteigenschaften

• Molekulargewicht: 451.34
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1597403-47-8]
• Formel: C22H24Cl2N2O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2alpha (eIF2alpha) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2beta.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid beta-induced neuronal cell death (12.5-25 nM) with no effect on amyloid beta production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6