Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2alpha (eIF2alpha) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2beta.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid beta-induced neuronal cell death (12.5-25 nM) with no effect on amyloid beta production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
* VAT and and shipping costs not included. Errors and price changes excepted
