ISRIB, CAS [[1597403-47-8]]

Product Overview

• Article Name: ISRIB, CAS [[1597403-47-8]]
• Biozol Catalog Number: FBM-10-1539
• Supplier Catalog Number: 10-1539
• Alternative Catalog Number: FBM-10-1539-5MG, FBM-10-1539-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N.N-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide. Alternate Names: trans-ISRIB

Product Description

Integrated stress response inhibitor

Product Properties

• Molecular Weight: 451.34
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1597403-47-8]
• Formula: C22H24Cl2N2O4

Application Notes

• Application Notes: Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2alpha (eIF2alpha) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2beta.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid beta-induced neuronal cell death (12.5-25 nM) with no effect on amyloid beta production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6