UNC-2170 HCl, CAS [[1648707-58-7]]

Produktübersicht

• Artikelname: UNC-2170 HCl, CAS [[1648707-58-7]]
• Artikelnummer: FBM-10-1558
• Hersteller Artikelnummer: 10-1558
• Alternativnummer: FBM-10-1558-5MG, FBM-10-1558-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride

Produktbeschreibung

Methyl-lysine binding protein inhibitor

Produkteigenschaften

• Molekulargewicht: 349.69
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1648707-58-7]
• Formel: C14H21BrN2O HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1