Chemical Name: 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Methyl-lysine binding protein inhibitor
Molecular Weight:
349.69
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[1648707-58-7]
Formula:
C14H21BrN2O HCl
Application Notes:
The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
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