NSC47924, CAS [[6638-24-0]]

Produktübersicht

• Artikelname: NSC47924, CAS [[6638-24-0]]
• Artikelnummer: FBM-10-1562
• Hersteller Artikelnummer: 10-1562
• Alternativnummer: FBM-10-1562-5MG,FBM-10-1562-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

PHLP phosphatase inhibitor / Laminin inhibitor

Produkteigenschaften

• Molekulargewicht: 279.33
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [6638-24-0]
• Formel: C18H17NO2

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 M).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 M) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3