NSC47924, CAS [[6638-24-0]]

Product Overview

• Article Name: NSC47924, CAS [[6638-24-0]]
• Biozol Catalog Number: FBM-10-1562
• Supplier Catalog Number: 10-1562
• Alternative Catalog Number: FBM-10-1562-5MG, FBM-10-1562-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-((4-Methoxyanilino)methyl)-2-naphthol

Product Description

PHLP phosphatase inhibitor / Laminin inhibitor

Product Properties

• Molecular Weight: 279.33
• Purity: 98% by TLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [6638-24-0]
• Formula: C18H17NO2

Application Notes

• Application Notes: A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 M).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 M) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3