Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
EP2 receptor antagonist
Molekulargewicht:
394.47
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[1164462-05-8]
Formel:
C23H26N2O4
Anwendungsbeschreibung:
Potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1
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