Chemical Name: (3E,7aR,12aS-7a-(1,1-Dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-1H,5H-imidazol[1,2:1,2]pyrido[2,3-b]indole-2,5(3H)-dione
Met inhibitor, Anticancer activity
Molekulargewicht:
433.46
Reinheit:
98% by HPLC, NMR (Conforms)
Formulierung:
Tan lyophilized solid
CAS Nummer:
[71751-77-4]
Formel:
C23H23N5O4
Anwendungsbeschreibung:
A novel alkaloid biosynthesized via the roquefortine branched biosynthetic pathway.1,2 Displays excellent ATP-competitive c-MET inhibition, inhibiting the growth, migration and invasion of numerous breast cancer cell lines.3 Also has been shown to inhibit the bacterial enoyl-acyl carrier protein reductase (Fabl) with IC50s in the 33-40 µM range.4
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