ST-034307, CAS [[133406-29-8]]

Produktübersicht

• Artikelname: ST-034307, CAS [[133406-29-8]]
• Artikelnummer: FBM-10-1620
• Hersteller Artikelnummer: 10-1620
• Alternativnummer: FBM-10-1620-5MG,FBM-10-1620-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Adenylate cyclase 1 inhibitor, analgesic activity

Produkteigenschaften

• Molekulargewicht: 297.95
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [133406-29-8]
• Formel: C10H4Cl4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 µM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Galphas-coupled receptors in HEK-AC1 cells. It enhanced µ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic µ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1