ST-034307, CAS [[133406-29-8]]

Product Overview

• Article Name: ST-034307, CAS [[133406-29-8]]
• Biozol Catalog Number: FBM-10-1620
• Supplier Catalog Number: 10-1620
• Alternative Catalog Number: FBM-10-1620-5MG, FBM-10-1620-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

Product Description

Adenylate cyclase 1 inhibitor, analgesic activity

Product Properties

• Molecular Weight: 297.95
• Purity: 98% by TLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [133406-29-8]
• Formula: C10H4Cl4O2

Application Notes

• Application Notes: A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 µM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Galphas-coupled receptors in HEK-AC1 cells. It enhanced µ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic µ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1