Potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of L-DOPA as adjunct therapy for Parkinsons disease.2 Inhibits alpha-synuclein aggregation in vitro and inhibits alpha-synuclein-induced cell death in PC-12 cells3. Antioxidant. Inhibits oxidative stress-induced cell death4.
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