Chemical Name: Fermentation product from Drechslera dematioidea. Alternate Names: NSC107658, Phominone, Phomin
Actin filament disrupting agent
Molekulargewicht:
479.61
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[14930-96-2]
Formel:
C29H37NO5
Anwendungsbeschreibung:
A cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization.1 Inhibits cell division, migration and glucose transport.2 Causes cell cycle arrest at G2/M and induces apoptosis in HCT-116 colorectal carcinoma cells.3 Cytochalasin B-induced membrane vesicles (CIMVs) retain cell surface receptors of the parent cells and retain fusion specificity with target cells.4 CIMVs are a promising new vector system for drug and biomolecule delivery due to their natural origin and participation in intercellular communication.5
10-2069
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