Chemical Name: Fermentation product from Streptomyces azureus
Antibiotic and FOXM1 inhibitor
Molekulargewicht:
1664.91
Reinheit:
98% by TLC and HPLC
Formulierung:
Off-white solid
CAS Nummer:
[1393-48-2]
Formel:
C72H85N19O18S5
Anwendungsbeschreibung:
Novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2)1-2. Displays antitumor activity. Induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression3.
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