Bosutinib, CAS [[380843-75-4]]

Produktübersicht

• Artikelname: Bosutinib, CAS [[380843-75-4]]
• Artikelnummer: FBM-10-2122
• Hersteller Artikelnummer: 10-2122
• Alternativnummer: FBM-10-2122-5MG, FBM-10-2122-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile. Alternate Names: SKI-606

Produktbeschreibung

Dual Src/Abl kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 530.45
• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [380843-75-4]
• Formel: C26H29Cl2N5O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5