Bosutinib, CAS [[380843-75-4]]

Product Overview

• Article Name: Bosutinib, CAS [[380843-75-4]]
• Biozol Catalog Number: FBM-10-2122
• Supplier Catalog Number: 10-2122
• Alternative Catalog Number: FBM-10-2122-5MG, FBM-10-2122-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile. Alternate Names: SKI-606

Product Description

Dual Src/Abl kinase inhibitor

Product Properties

• Molecular Weight: 530.45
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [380843-75-4]
• Formula: C26H29Cl2N5O3

Application Notes

• Application Notes: An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5