Chemical Name: N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
MEK inhibitor
Molekulargewicht:
482.20
Reinheit:
98%, NMR Conforms
Formulierung:
White solid
CAS Nummer:
[391210-10-9]
Formel:
C16H14F3IN2O4
Anwendungsbeschreibung:
A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5
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