Pemetrexed, CAS [[357166-29-1]]

Produktübersicht

• Artikelname: Pemetrexed, CAS [[357166-29-1]]
• Artikelnummer: FBM-10-2162
• Hersteller Artikelnummer: 10-2162
• Alternativnummer: FBM-10-2162-10MG, FBM-10-2162-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt. Alternate Names: LY231514

Produktbeschreibung

Antifolate, antitumor agent

Produkteigenschaften

• Molekulargewicht: 597.49
• Reinheit: 98% by TLC and HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [357166-29-1]
• Formel: C20H19N5O6 2Na 7H2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 µM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 µM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5