Pemetrexed, CAS [[357166-29-1]]

Product Overview

• Article Name: Pemetrexed, CAS [[357166-29-1]]
• Biozol Catalog Number: FBM-10-2162
• Supplier Catalog Number: 10-2162
• Alternative Catalog Number: FBM-10-2162-10MG,FBM-10-2162-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt. Alternate Names: LY231514

Product Description

Antifolate, antitumor agent

Product Properties

• Molecular Weight: 597.49
• Purity: 98% by TLC and HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [357166-29-1]
• Formula: C20H19N5O6 2Na 7H2O

Application Notes

• Application Notes: Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 µM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 µM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5

Images

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