Chemical Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide. Alternate Names: RS-34821
Immunosuppressant
Molekulargewicht:
270.21
Reinheit:
98% by TLC, NMR (conforms)
Formulierung:
White solid
CAS Nummer:
[75706-12-6]
Formel:
C12H9F3N2O2
Anwendungsbeschreibung:
A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury3.
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