Mizoribine, CAS [[50924-49-7]]

Produktübersicht

• Artikelname: Mizoribine, CAS [[50924-49-7]]
• Artikelnummer: FBM-10-2434
• Hersteller Artikelnummer: 10-2434
• Alternativnummer: FBM-10-2434-20MG, FBM-10-2434-100MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N'-(beta-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide. Alternate Names: NSC-289637

Produktbeschreibung

Immunosuppressant

Produkteigenschaften

• Molekulargewicht: 259.22
• Reinheit: >98% by TLC, NMR (conforms)
• Formulierung: Off-white solid
• CAS Nummer: [50924-49-7]
• Formel: C9H13N3O6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Mizoribine is an immunosuppressant nucleoside natural product first isolated from Eupenicillium brefeldianum.1 Inhibits inosine monophosphate dehydrogenase, suppressing T-cell proliferation via depletion of guanine ribonucleotides.2 Reduces cellular GTP levels in CEM leukemia cells (68% at 4 mM and 2 hours).3 Selectively attenuates the expression of monocyte chemoattractant protein 1.4 Mizoribine also acts at HSP60, and induces an HSP60/HSP10 complex which consequently suppresses IL-6 expression.5 It displays anti-proteinuric effects by restoring normal nephrin biogenesis in nephrotic syndrome models.6