Mizoribine, CAS [[50924-49-7]]

Product Overview

• Article Name: Mizoribine, CAS [[50924-49-7]]
• Biozol Catalog Number: FBM-10-2434
• Supplier Catalog Number: 10-2434
• Alternative Catalog Number: FBM-10-2434-20MG, FBM-10-2434-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N'-(beta-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide. Alternate Names: NSC-289637

Product Description

Immunosuppressant

Product Properties

• Molecular Weight: 259.22
• Purity: >98% by TLC, NMR (conforms)
• Form: Off-white solid
• CAS Number: [50924-49-7]
• Formula: C9H13N3O6

Application Notes

• Application Notes: Mizoribine is an immunosuppressant nucleoside natural product first isolated from Eupenicillium brefeldianum.1 Inhibits inosine monophosphate dehydrogenase, suppressing T-cell proliferation via depletion of guanine ribonucleotides.2 Reduces cellular GTP levels in CEM leukemia cells (68% at 4 mM and 2 hours).3 Selectively attenuates the expression of monocyte chemoattractant protein 1.4 Mizoribine also acts at HSP60, and induces an HSP60/HSP10 complex which consequently suppresses IL-6 expression.5 It displays anti-proteinuric effects by restoring normal nephrin biogenesis in nephrotic syndrome models.6