Pifithrin alpha (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2 Supresses self-renewal of embryonic stem cells.5 Pfithrin alpha protects against neuronal death in models of stroke and neurodegenerative disease.3 AhR agonist.4
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