Chemical Name: 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone HBr. Alternate Names: PFT-alpha
p53 inhibitor
Molecular Weight:
367.31
Purity:
98% by TLC, NMr (Conforms)
Form:
White solid
CAS Number:
[63208-82-2]
Formula:
C16 H18 N2 O S H Br
Application Notes:
Pifithrin alpha (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2 Supresses self-renewal of embryonic stem cells.5 Pfithrin alpha protects against neuronal death in models of stroke and neurodegenerative disease.3 AhR agonist.4
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