Potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases1. Mobilizes intracellular Ca2+ in dermal fibroblasts2. Inhibits LIM-kinase, impairing cell migration and invasion3. A potent inhibitor of angiogenesis4. Inhibits mast cell activation5.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten