Splitomicin, CAS [[5690-03-9]]

Produktübersicht

• Artikelname: Splitomicin, CAS [[5690-03-9]]
• Artikelnummer: FBM-10-2615
• Hersteller Artikelnummer: 10-2615
• Alternativnummer: FBM-10-2615-5MG, FBM-10-2615-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Produktbeschreibung

Sirt1 inhibitor

Produkteigenschaften

• Molekulargewicht: 198.22
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [5690-03-9]
• Formel: C13H10O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.