Splitomicin, CAS [[5690-03-9]]

Product Overview

• Article Name: Splitomicin, CAS [[5690-03-9]]
• Biozol Catalog Number: FBM-10-2615
• Supplier Catalog Number: 10-2615
• Alternative Catalog Number: FBM-10-2615-5MG, FBM-10-2615-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Product Description

Sirt1 inhibitor

Product Properties

• Molecular Weight: 198.22
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [5690-03-9]
• Formula: C13H10O2

Application Notes

• Application Notes: Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.