Chemical Name: (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester. Alternate Names: NSC59272
VMAT1,2 inhibitor
Molekulargewicht:
608.68
Reinheit:
98% by TLC NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[50-55-5]
Formel:
C33H40N2O9
Anwendungsbeschreibung:
Indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively.1,2 May be used to pharmacologically deplete monoamines in various animal models.3 Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 mM.3 Reserpine-induced hypokinesia is considered a useful animal model of Parkinsons disease.5
10-2689
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