Chemical Name: (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester. Alternate Names: NSC59272
VMAT1,2 inhibitor
Molecular Weight:
608.68
Purity:
98% by TLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[50-55-5]
Formula:
C33H40N2O9
Application Notes:
Indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively.1,2 May be used to pharmacologically deplete monoamines in various animal models.3 Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 mM.3 Reserpine-induced hypokinesia is considered a useful animal model of Parkinsons disease.5
* VAT and and shipping costs not included. Errors and price changes excepted
