Pomalidomide, CAS [[19171-19-8]]

Produktübersicht

• Artikelname: Pomalidomide, CAS [[19171-19-8]]
• Artikelnummer: FBM-10-2768
• Hersteller Artikelnummer: 10-2768
• Alternativnummer: FBM-10-2768-20MG, FBM-10-2768-100MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide. Alternate Names: 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide

Produktbeschreibung

Cereblon ubiquitination inhibitor

Produkteigenschaften

• Molekulargewicht: 273.24
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [19171-19-8]
• Formel: C13H11N3O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5