Pomalidomide, CAS [[19171-19-8]]

Product Overview

• Article Name: Pomalidomide, CAS [[19171-19-8]]
• Biozol Catalog Number: FBM-10-2768
• Supplier Catalog Number: 10-2768
• Alternative Catalog Number: FBM-10-2768-20MG,FBM-10-2768-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide

Product Description

Cereblon ubiquitination inhibitor

Product Properties

• Molecular Weight: 273.24
• Purity: 98% by TLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [19171-19-8]
• Formula: C13H11N3O4

Application Notes

• Application Notes: Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5