Chemical Name: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide. Alternate Names: FCE-26743, PNU-151774E, NW-1015
MAO-B inhibitor, Parkinsons therapeutic
Molekulargewicht:
302.34
Reinheit:
98% by HPLC NMr (Conforms)
Formulierung:
White solid
CAS Nummer:
[133865-89-1]
Formel:
C17H19FN2O2
Anwendungsbeschreibung:
A selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A.1 Displays anticonvulsant activity2 and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models3. Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade.4 A novel therapeutic for Parkinsons disease with multiple modes of action.5 Effective as an add-on to dopamine agonist therapy in early Parkinsons.6
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